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Index > Protein center > LTF(Gene name) > Human
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  • LTF (Gene name),
  • Lactotransferrin (Protein name ),  TRFL_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    LTF(LF;LF);
    Protein name:
    Lactotransferrin(Lactoferrin);
    Alternative:
    Talalactoferrin;Talalactoferrin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    710
    Sequence:
    50:
    MKLVFLVLLF | LGALGLCLAG | RRRSVQWCAV | SQPEATKCFQ | WQRNMRKVRG | 
    100:
    PPVSCIKRDS | PIQCIQAIAE | NRADAVTLDG | GFIYEAGLAP | YKLRPVAAEV | 
    150:
    YGTERQPRTH | YYAVAVVKKG | GSFQLNELQG | LKSCHTGLRR | TAGWNVPIGT | 
    200:
    LRPFLNWTGP | PEPIEAAVAR | FFSASCVPGA | DKGQFPNLCR | LCAGTGENKC | 
    250:
    AFSSQEPYFS | YSGAFKCLRD | GAGDVAFIRE | STVFEDLSDE | AERDEYELLC | 
    300:
    PDNTRKPVDK | FKDCHLARVP | SHAVVARSVN | GKEDAIWNLL | RQAQEKFGKD | 
    350:
    KSPKFQLFGS | PSGQKDLLFK | DSAIGFSRVP | PRIDSGLYLG | SGYFTAIQNL | 
    400:
    RKSEEEVAAR | RARVVWCAVG | EQELRKCNQW | SGLSEGSVTC | SSASTTEDCI | 
    450:
    ALVLKGEADA | MSLDGGYVYT | AGKCGLVPVL | AENYKSQQSS | DPDPNCVDRP | 
    500:
    VEGYLAVAVV | RRSDTSLTWN | SVKGKKSCHT | AVDRTAGWNI | PMGLLFNQTG | 
    550:
    SCKFDEYFSQ | SCAPGSDPRS | NLCALCIGDE | QGENKCVPNS | NERYYGYTGA | 
    600:
    FRCLAENAGD | VAFVKDVTVL | QNTDGNNNEA | WAKDLKLADF | ALLCLDGKRK | 
    650:
    PVTEARSCHL | AMAPNHAVVS | RMDKVERLKQ | VLLHQQAKFG | RNGSDCPDKF | 
    700:
    CLFQSETKNL | LFNDNTECLA | RLHGKTTYEK | YLGPQYVAGI | TNLKKCSTSP | 
    710:
    LLEACEFLRK | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    MIM:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Lactoferrin
    Cat.:
    E0780h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Lactoferrin
    Cat.:
    E0780m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Lactoferrin
    Cat.:
    E0780b
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Lactoferrin
    Cat.:
    E0780p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Lactoferrin
    Cat.:
    U0780h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Lactoferrin
    Cat.:
    U0780b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Lactoferrin
    Cat.:
    U0780p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Lactoferrin
    Cat.:
    U0780m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Lactoferrin
    Polyclonal Antibody for Human Lactoferrin
    Polyclonal Antibody for Human Lactoferrin
    Cat.:
    P0780Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Lactoferrin
    Cat.:
    P0780Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Lactoferrin
    Monoclonal Antibody for Human Lactoferrin
    Monoclonal Antibody for Human Lactoferrin
    Monoclonal Antibody for Human Lactoferrin
    Protein for Human Lactoferrin
    Protein for Human Lactoferrin
    Protein for Human Lactoferrin
    Protein for Human Lactoferrin

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete nucleotide sequence of human mammary gland lactoferrin."
      Rey M.W. , Woloshuk S.L. , de Boer H.A. , Pieper F.R.
      Nucleic Acids Res.18:5288-5288(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-22 INS; THR-148 AND CYS-422
      tissue: Mammary gland.
    2. 2.
      "Cloning of human lactoferrin gene and its polymorphism in normal and cancer cells."
      Cho Y.Y.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-22 INS
      tissue: Mammary gland.
    3. 3.
      "Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor-derived cell lines."
      Siebert P.D. , Huang B.C.
      Proc. Natl. Acad. Sci. U.S.A.94:2198-2203(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND DELTALF);ALTERNATIVE SPLICING;TISSUE SPECIFICITY
      tissue: Lung.
    4. 4.
      "cDNA cloning and sequence analysis of human lactoferrin."
      Cheng H. , Chen X.Z. , Huan L.D.
      Sheng Wu Gong Cheng Xue Bao17:385-387(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-22 INS; THR-29; ARG-47 AND ASP-579
      tissue: Mammary gland.
    5. 5.
      "Crystal structure of human seminal diferric lactoferrin at 3.4 Angstrom resolution."
      Kumar J. , Weber W. , Munchau S. , Yadav S. , Singh S.B. , Saravanan K. , Paramasivam M. , Sharma S. , Kaur P. , Bhushan A. , Srinivasan A. , Betzel C. , Singh T.P.
      Indian J. Biochem. Biophys.40:14-21(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);X-RAY CRYSTALLOGRAPHY (3.40 ANGSTROMS) OF 22-710 IN COMPLEX WITH IRON AND CARBONATE;VARIANTS ARG-22 INS; THR-29; ARG-47 AND ASP-579
      tissue: Seminal vesicle.
    6. 6.
      "One of two human lactoferrin variants exhibits increased antibacterial and transcriptional activation activities and is associated with localized juvenile periodontitis."
      Velliyagounder K. , Kaplan J.B. , Furgang D. , Legarda D. , Diamond G. , Parkin R.E. , Fine D.H.
      Infect. Immun.71:6141-6147(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 20-30;FUNCTION;VARIANTS ARG-22 INS; THR-29 AND ARG-47
      tissue: Blood.
    7. 7.
      "Human neutrophil lactoferrin coding and 5' flanking region DNA sequences."
      Wei X. , Han J. , Rado T.A.
      Submitted (1992-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Bone marrow.
    8. 8.
      Conneely O.M.
      Submitted (1992-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-22 INS; THR-29 AND ARG-47
      tissue: Prostate.
    9. 9.
      Shi Y.-Q. , Zhang Y. , Zheng Y.-M.
      Submitted (2002-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-22 INS; THR-29; ARG-47 AND ASP-579
      tissue: Mammary gland.
    10. 10.
      "Identification of a growth inhibition gene."
      Kim J.W.
      Submitted (2003-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-22 INS AND CYS-422
    11. 11.
      "Mutations in ELA2 and LTF genes."
      Allayous C. , Marianne-Pepin T.
      Submitted (2008-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-22 INS; THR-29 AND ARG-47
    12. 12.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND DELTALF);VARIANT ARG-22 INS
      tissue: Lung.
      tissue: Trachea.
    13. 13.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    14. 14.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-22 INS
      tissue: Prostate.
    15. 15.
      "Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse."
      Teng C.T. , Liu Y. , Yang N. , Walmer D. , Panella T.
      Mol. Endocrinol.6:1969-1981(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15
    16. 16.
      "Nucleotide sequence of human lactoferrin cDNA."
      Powell M.J. , Ogden J.E.
      Nucleic Acids Res.18:4013-4013(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-710 (ISOFORM 1);VARIANT ARG-22 INS
      tissue: Mammary gland.
    17. 17.
      "Molecular cloning and sequence analysis of human lactoferrin."
      Liang Q. , Jimenez-Flores R. , Richardson T.
      Submitted (1991-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-710 (ISOFORM 1);VARIANT ARG-22 INS
      tissue: Mammary gland.
    18. 18.
      "Human lactotransferrin: amino acid sequence and structural comparisons with other transferrins."
      Metz-Boutigue M.-H. , Jolles J. , Mazurier J. , Schoentgen F. , Legrand D. , Spik G. , Montreuil J. , Jolles P.
      Eur. J. Biochem.145:659-676(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-710 (ISOFORM 1);DISULFIDE BONDS
    19. 19.
      "The present state of the human lactotransferrin sequence. Study and alignment of the cyanogen bromide fragments and characterization of N- and C-terminal domains."
      Metz-Boutigue M.-H. , Mazurier J. , Jolles J. , Spik G. , Montreuil J. , Jolles P.
      Biochim. Biophys. Acta670:243-254(1981) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY PROTEIN SEQUENCE OF 20-72; 133-170; 256-277; 359-528 AND 608-663 (ISOFORM 1)
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-65 (ISOFORM 1);IDENTIFICATION OF LACTOFERRICIN PEPTIDE;FUNCTION;SYNTHESIS OF 36-58
      tissue: Milk.
    21. 21.
      "Delineation of the glycosaminoglycan-binding site in the human inflammatory response protein lactoferrin."
      Mann D.M. , Romm E. , Migliorini M.
      J. Biol. Chem.269:23661-23667(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-40 (ISOFORM 1);FUNCTION;GLYCOSAMINOGLYCAN BINDING;SYNTHESIS OF 20-51; 20-45 AND 25-51
      tissue: Milk.
    22. 22.
      "Characterization of the 84-kDa protein with ABH activity in human seminal plasma."
      Sato I.
      Nihon Hoigaku Zasshi49:281-293(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-56 (ISOFORM 1)
      tissue: Seminal plasma.
    23. 23.
      "Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent."
      Hunter H.N. , Demcoe A.R. , Jenssen H. , Gutteberg T.J. , Vogel H.J.
      Antimicrob. Agents Chemother.49:3387-3395(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-32; 38-43; 50-57 AND 59-67 (ISOFORM 1);STRUCTURE BY NMR OF 20-67 (LACTOFERRICIN);MASS SPECTROMETRY;DISULFIDE BONDS
      tissue: Milk.
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 236-710;VARIANT ASP-579
    25. 25.
      "Isolation of lactoferrin cDNA from a human myeloid library and expression of mRNA during normal and leukemic myelopoiesis."
      Rado T.A. , Wei X. , Benz E.J. Jr.
      Blood70:989-993(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 435-710
      tissue: Myeloid.
    26. 26.
      "An 88 amino acid long C-terminal sequence of human lactotransferrin."
      Metz-Boutigue M.-H. , Jolles J. , Mazurier J. , Spik G. , Montreuil J. , Jolles P.
      FEBS Lett.142:107-110(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 608-710
    27. 27.
      "Bactericidal activity of human lactoferrin: differentiation from the stasis of iron deprivation."
      Arnold R.R. , Russell J.E. , Champion W.J. , Brewer M. , Gauthier J.J.
      Infect. Immun.35:792-799(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    28. 28.
      "Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold."
      Cramer E. , Pryzwansky K.B. , Villeval J.L. , Testa U. , Breton-Gorius J.
      Blood65:423-432(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    29. 29.
      "Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin."
      Ellison R.T. III , Giehl T.J. , LaForce F.M.
      Infect. Immun.56:2774-2781(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    30. 30.
      "Isolation and characterization of opioid antagonist peptides derived from human lactoferrin."
      Tani F. , Iio K. , Chiba H. , Yoshikawa M.
      Agric. Biol. Chem.54:1803-1810(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF LACTOFERROXINS
    31. 31.
      "N-terminal stretch Arg2, Arg3, Arg4 and Arg5 of human lactoferrin is essential for binding to heparin, bacterial lipopolysaccharide, human lysozyme and DNA."
      van Berkel P.H. , Geerts M.E. , van Veen H.A. , Mericskay M. , de Boer H.A. , Nuijens J.H.
      Biochem. J.328:145-151(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF 20-G--R-23
    32. 32.
      "Candidacidal activities of human lactoferrin peptides derived from the N terminus."
      Lupetti A. , Paulusma-Annema A. , Welling M.M. , Senesi S. , van Dissel J.T. , Nibbering P.H.
      Antimicrob. Agents Chemother.44:3257-3263(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    33. 33.
      "Expression of lactoferrin in the kidney: implications for innate immunity and iron metabolism."
      Abrink M. , Larsson E. , Gobl A. , Hellman L.
      Kidney Int.57:2004-2010(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    34. 34.
      "Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria."
      Nibbering P.H. , Ravensbergen E. , Welling M.M. , van Berkel L.A. , van Berkel P.H. , Pauwels E.K. , Nuijens J.H.
      Infect. Immun.69:1469-1476(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SYNTHESIS OF 20-29 AND 39-49;MUTAGENESIS OF 20-GLY--ARG-22
    35. 35.
      "A component of innate immunity prevents bacterial biofilm development."
      Singh P.K. , Parsek M.R. , Greenberg E.P. , Welsh M.J.
      Nature417:552-555(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    36. 36.
      "An intronic alternative promoter of the human lactoferrin gene is activated by Ets."
      Liu D. , Wang X. , Zhang Z. , Teng C.T.
      Biochem. Biophys. Res. Commun.301:472-479(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;ALTERNATIVE PROMOTER USAGE
    37. 37.
      "Potassium efflux induced by a new lactoferrin-derived peptide mimicking the effect of native human lactoferrin on the bacterial cytoplasmic membrane."
      Viejo-Diaz M. , Andres M.T. , Perez-Gil J. , Sanchez M. , Fierro J.F.
      Biochemistry (Mosc.)68:217-227(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SYNTHESIS OF 36-58 AND 171-201 (KALIOCIN-1)
    38. 38.
      "Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine-rich sites."
      Hendrixson D.R. , Qiu J. , Shewry S.C. , Fink D.L. , Petty S. , Baker E.N. , Plaut A.G. , St Geme J.W. III
      Mol. Microbiol.47:607-617(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A PROTEASE;MUTAGENESIS OF LYS-92; PRO-270 AND SER-278
    39. 39.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION (DELTALF)
    40. 40.
      "Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo."
      Cornish J. , Callon K.E. , Naot D. , Palmano K.P. , Banovic T. , Bava U. , Watson M. , Lin J.M. , Tong P.C. , Chen Q. , Chan V.A. , Reid H.E. , Fazzalari N. , Baker H.M. , Baker E.N. , Haggarty N.W. , Grey A.B. , Reid I.R.
      Endocrinology145:4366-4374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    41. 41.
      "Human lactoferrin upregulates expression of KDR/Flk-1 and stimulates VEGF-A-mediated endothelial cell proliferation and migration."
      Kim C.W. , Son K.N. , Choi S.Y. , Kim J.
      FEBS Lett.580:4332-4336(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    42. 42.
      "The anti-papillomavirus activity of human and bovine lactoferricin."
      Mistry N. , Drobni P. , Naslund J. , Sunkari V.G. , Jenssen H. , Evander M.
      Antiviral Res.75:258-265(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    43. 43.
      "Characterization of an eppin protein complex from human semen and spermatozoa."
      Wang Z. , Widgren E.E. , Richardson R.T. , O'Rand M.G.
      Biol. Reprod.77:476-484(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH CLU; SEMG1 AND EPPIN
    44. 44.
      "Adenoviruses use lactoferrin as a bridge for CAR-independent binding to and infection of epithelial cells."
      Johansson C. , Jonsson M. , Marttila M. , Persson D. , Fan X.L. , Skog J. , Frangsmyr L. , Wadell G. , Arnberg N.
      J. Virol.81:954-963(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    45. 45.
      "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
      Picariello G. , Ferranti P. , Mamone G. , Roepstorff P. , Addeo F.
      Proteomics8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-156; ASN-497 AND ASN-642
      tissue: Milk.
    46. 46.
      "Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin."
      Bournazou I. , Pound J.D. , Duffin R. , Bournazos S. , Melville L.A. , Brown S.B. , Rossi A.G. , Gregory C.D.
      J. Clin. Invest.119:20-32(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    47. 47.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-497
      tissue: Liver.
    48. 48.
      "Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling."
      Ando K. , Hasegawa K. , Shindo K. , Furusawa T. , Fujino T. , Kikugawa K. , Nakano H. , Takeuchi O. , Akira S. , Akiyama T. , Gohda J. , Inoue J. , Hayakawa M.
      FEBS J.277:2051-2066(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PTM
    49. 49.
      "O-GlcNAcylation/phosphorylation cycling at Ser10 controls both transcriptional activity and stability of delta-lactoferrin."
      Hardiville S. , Hoedt E. , Mariller C. , Benaissa M. , Pierce A.
      J. Biol. Chem.285:19205-19218(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;PHOSPHORYLATION AT SER-10 (ISOFORM DELTALF);UBIQUITINATION (ISOFORM DELTALF)
    50. 50.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    51. 51.
      "Delta-lactoferrin, an intracellular lactoferrin isoform that acts as a transcription factor."
      Mariller C. , Hardiville S. , Hoedt E. , Huvent I. , Pina-Canseco S. , Pierce A.
      Biochem. Cell Biol.90:307-319(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A TRANSCRIPTION FACTOR (ISOFORM DELTALF);DNA-BINDING (ISOFORM DELTALF)
    52. 52.
      "Structure of human lactoferrin: crystallographic structure analysis and refinement at 2.8-A resolution."
      Anderson B.F. , Baker H.M. , Norris G.E. , Rice D.W. , Baker E.N.
      J. Mol. Biol.209:711-734(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS);SEQUENCE REVISION
    53. 53.
      "Molecular replacement solution of the structure of apolactoferrin, a protein displaying large-scale conformational change."
      Norris G.E. , Anderson B.F. , Baker E.N.
      Acta Crystallogr. B47:998-1004(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 20-710
    54. 54.
      "Metal substitution in transferrins: the crystal structure of human copper-lactoferrin at 2.1-A resolution."
      Smith C.A. , Anderson B.F. , Baker H.M. , Baker E.N.
      Biochemistry31:4527-4533(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 20-710 IN COMPLEX WITH COPPER AND CARBONATE;GLYCOSYLATION AT ASN-156 AND ASN-497
    55. 55.
      "Structure of the recombinant N-terminal lobe of human lactoferrin at 2.0 A resolution."
      Day C.L. , Anderson B.F. , Tweedie J.W. , Baker E.N.
      J. Mol. Biol.232:1084-1100(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 21-352 IN COMPLEX WITH IRON AND CARBONATE;DISULFIDE BONDS
    56. 56.
      "Structure of copper- and oxalate-substituted human lactoferrin at 2.0 A resolution."
      Smith C.A. , Anderson B.F. , Baker H.M. , Baker E.N.
      Acta Crystallogr. D50:302-316(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 20-710 IN COMPLEX WITH COPPER AND OXALATE;GLYCOSYLATION AT ASN-156
    57. 57.
      "Structures of a legume lectin complexed with the human lactotransferrin N2 fragment, and with an isolated biantennary glycopeptide: role of the fucose moiety."
      Bourne Y. , Mazurier J. , Legrand D. , Rouge P. , Montreuil J. , Spik G. , Cambillau C.
      Structure2:209-219(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS) OF 110-268;GLYCOSYLATION AT ASN-156
    58. 58.
      "Structure of human diferric lactoferrin refined at 2.2-A resolution."
      Haridas M. , Anderson B.F. , Baker E.N.
      Acta Crystallogr. D51:629-646(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 20-710 IN COMPLEX WITH IRON AND CARBONATE;GLYCOSYLATION AT ASN-156 AND ASN-497
    59. 59.
      "Anion binding by transferrins: importance of second-shell effects revealed by the crystal structure of oxalate-substituted diferric lactoferrin."
      Baker H.M. , Anderson B.F. , Brodie A.M. , Shongwe M.S. , Smith C.A. , Baker E.N.
      Biochemistry35:9007-9013(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 20-710 IN COMPLEX WITH IRON AND OXALATE
    60. 60.
      "Mutation of arginine 121 in lactoferrin destabilizes iron binding by disruption of anion binding: crystal structures of R121S and R121E mutants."
      Faber H.R. , Baker C.J. , Day C.L. , Tweedie J.W. , Baker E.N.
      Biochemistry35:14473-14479(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 22-352 OF MUTANTS GLU-140 AND SER-140 IN COMPLEX WITH IRON AND CARBONATE;MUTAGENESIS OF ARG-140
    61. 61.
      "Altered domain closure and iron binding in transferrins: the crystal structure of the Asp60Ser mutant of the amino-terminal half-molecule of human lactoferrin."
      Faber H.R. , Bland T. , Day C.L. , Norris G.E. , Tweedie J.W. , Baker E.N.
      J. Mol. Biol.256:352-363(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 21-352 OF MUTANT SER-79 IN COMPLEX WITH IRON AND CARBONATE;MUTAGENESIS OF ASP-79
    62. 62.
      "Mutagenesis of the histidine ligand in human lactoferrin: iron binding properties and crystal structure of the histidine-253-->methionine mutant."
      Nicholson H. , Anderson B.F. , Bland T. , Shewry S.C. , Tweedie J.W. , Baker E.N.
      Biochemistry36:341-346(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 21-353 OF MUTANT MET-272 IN COMPLEX WITH IRON AND CARBONATE;MUTAGENESIS OF HIS-272
    63. 63.
      "Structure of human apolactoferrin at 2.0 A resolution. Refinement and analysis of ligand-induced conformational change."
      Jameson G.B. , Anderson B.F. , Norris G.E. , Thomas D.H. , Baker E.N.
      Acta Crystallogr. D54:1319-1335(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 20-710
    64. 64.
      "Structure of recombinant human lactoferrin expressed in Aspergillus awamori."
      Sun X.L. , Baker H.M. , Shewry S.C. , Jameson G.B. , Baker E.N.
      Acta Crystallogr. D55:403-407(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) 20-710 IN COMPLEX WITH IRON AND CARBONATE
    65. 65.
      "Crystal structure and iron-binding properties of the R210K mutant of the N-lobe of human lactoferrin: implications for iron release from transferrins."
      Peterson N.A. , Anderson B.F. , Jameson G.B. , Tweedie J.W. , Baker E.N.
      Biochemistry39:6625-6633(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 21-348 OF MUTANT LYS-229 IN COMPLEX WITH IRON AND CARBONATE;MUTAGENESIS OF ARG-229
    66. 66.
      "Metal substitution in transferrins: specific binding of cerium(IV) revealed by the crystal structure of cerium-substituted human lactoferrin."
      Baker H.M. , Baker C.J. , Smith C.A. , Baker E.N.
      J. Biol. Inorg. Chem.5:692-698(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 21-710 IN COMPLEX WITH CERIUM AND CARBONATE
    67. 67.
      "Structure of a domain-opened mutant (R121D) of the human lactoferrin N-lobe refined from a merohedrally twinned crystal form."
      Jameson G.B. , Anderson B.F. , Breyer W.A. , Day C.L. , Tweedie J.W. , Baker E.N.
      Acta Crystallogr. D58:955-962(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 21-351 OF MUTANT ASP-140;MUTAGENESIS OF ARG-140
    68. 68.
      "'Dilysine trigger' in transferrins probed by mutagenesis of lactoferrin: crystal structures of the R210G, R210E, and R210L mutants of human lactoferrin."
      Peterson N.A. , Arcus V.L. , Anderson B.F. , Tweedie J.W. , Jameson G.B. , Baker E.N.
      Biochemistry41:14167-14175(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 21-352 OF MUTANTS GLY-229; GLU-229 AND LEU-229 IN COMPLEX WITH IRON AND CARBONATE;MUTAGENESIS OF ARG-229
    69. 69.
      "Structure of human diferric lactoferrin at 2.5A resolution using crystals grown at pH 6.5."
      Vikram P. , Prem Kumar R. , Singh N. , Kumar J. , Ethayathulla A.S. , Sharma S. , Kaur P. , Singh T.P.
      Submitted (2004-03) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 20-710 IN COMPLEX WITH IRON AND CARBONATE;GLYCOSYLATION AT ASN-156 AND ASN-497
    70. 70.
      "Structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide."
      Japelj B. , Pristovsek P. , Majerle A. , Jerala R.
      J. Biol. Chem.280:16955-16961(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 39-49 IN COMPLEX WITH LIPOPOLYSACCHARIDE;SYNTHESIS OF 39-49
    71. 71.
      "The protein structure of recombinant human lactoferrin produced in the milk of transgenic cows closely matches the structure of human milk-derived lactoferrin."
      Thomassen E.A. , van Veen H.A. , van Berkel P.H. , Nuijens J.H. , Abrahams J.P.
      Transgenic Res.14:397-405(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 20-710 IN COMPLEX WITH IRON AND CARBONATE;GLYCOSYLATION AT ASN-156 AND ASN-497;VARIANT ASP-579
    72. 72.
      "Crystal structure of the complex formed between proteinase K and a human lactoferrin fragment at 2.9 A resolution."
      Singh A.K. , Singh N. , Sharma S. , Bhushan A. , Singh T.P.
      Submitted (2006-05) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 528-535 IN COMPLEX WITH PROTEINASE K
    73. 73.
      "Crystal structure of proteinase K inhibited by a lactoferrin octapeptide Gly-Asp-Glu-Gln-Gly-Glu-Asn-Lys at 2.15 A resolution."
      Prem Kumar R. , Singh A.K. , Singh N. , Kaur P. , Sharma S. , Singh T.P.
      Submitted (2006-06) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 528-535 IN COMPLEX WITH PROTEINASE K
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      "The acyl group as the central element of the structural organization of antimicrobial lipopeptide."
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